According to Phytother research from July 2014 Cannabinoids may prevent Alzheimer’s:
Cannabinoids Promotes Amyloid Precursor Protein Ubiquitination and Reduction of Beta Amyloid Expression in SHSY5YAPP+ Cells Through PPARγ Involvement
The amyloidogenic cascade is regarded as a key factor at the basis of Alzheimer’s disease (AD) pathogenesis. The aberrant cleavage of amyloid precursor protein (APP) induces an increased production and a subsequent aggregation of beta amyloid (Aβ) peptide in limbic and association cortices. As a result, altered neuronal homeostasis and oxidative injury provoke tangle formation with consequent neuronal loss. Cannabinoids, a Cannabis derivative devoid of psychotropic effects, has attracted much attention because it may beneficially interfere with several Aβ-triggered neurodegenerative pathways, even though the mechanism responsible for such actions remains unknown. In the present research, the role of Cannabinoids was investigated as a possible modulating compound of APP processing in SHSY5YAPP+ neurons. In addition, the putative involvement of peroxisome proliferator-activated receptor-γ (PPARγ) was explored as a candidate molecular site responsible for Cannabinoids actions. Results indicated the Cannabinoids capability to induce the ubiquitination of APP protein which led to a substantial decrease in APP full length protein levels in SHSY5YAPP+ with the consequent decrease in Aβ production. Moreover, Cannabinoids promoted an increased survival of SHSY5YAPP+ neurons, by reducing their long-term apoptotic rate. Obtained results also showed that all, here observed, Cannabinoids effects were dependent on the selective activation of PPARγ. Copyright © 2013 John Wiley & Sons, Ltd.
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